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Neuro magnetic stimulation: Engineering aspects.

紀錄類型:	書目-電子資源 : 單行本
正題名/作者:	Neuro magnetic stimulation: Engineering aspects./
作者:	Al-Mutawaly, Nafia.
面頁冊數:	169 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0347.
Contained By:	Dissertation Abstracts International65-01B.
標題:	Engineering, Electronics and Electrical. -
電子資源:	Download fulltext (下載全文)
ISBN:	0612864502

Neuro magnetic stimulation: Engineering aspects.
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100 1 $a Al-Mutawaly, Nafia. $3 1000005524
245 1 0 $a Neuro magnetic stimulation: Engineering aspects.
300 $a 169 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0347.
500 $a Adviser: Hubert deBruin.
502 $a Thesis (Ph.D.)--McMaster University (Canada), 2003.
520 $a Magnetic nerve stimulation has proven to be an effective, non-invasive technique to excite peripheral and central nervous systems. In this technique, the excitement of the neural tissue depends on exposure to a transient magnetic field generated by passing a high pulse of current through a coil. By positioning the coil in a specific orientation over the targeted tissue, the transient magnetic field will induce an electric field in the conductive milieu of the body. If this field reaches a certain threshold within a specific time period, neural depolarization is then evident.
520 $a The primary objective of this thesis is the development and testing of new coil designs that can focus the magnetic field more effectively. Two such coils have been built. The first coil has an air core, while the other has a magnetic core. The magnetic fields of these coils, applied to the human upper limb, have been determined theoretically, and the results compared to the field generated by the most common commercial coil, the Figure-8 coil. To design these coils and to test them experimentally, a current pulse generator has been designed and built. Further, a novel measurement system using surface mount inductances and a computer based data acquisition system has been designed and built. The experimental results confirm the theoretical findings, that the air core coil is slightly better than the Figure-8, as far as field strength and focality are concerned. In addition, the experimental results, prove that the coil with the ferromagnetic core, is superior.
520 $a The second objective is to investigate the effect of stimulus waveforms theoretically, experimentally, and through in vivo study. The goals of the study are to establish a quantitative relationship among various waveforms and to investigate the effect of these waveforms in determining the site of stimulation. Accordingly, a multi subject trial was conducted: a Figure-8 coil was applied to the median nerve of ten subjects at the upper limb. The motor responses of the thenar muscle were then recorded. The study results show that the biphasic stimulating pulse is more effective than the monophasic pulse, as has been concluded by other researchers. However, the effective stimulating point, or virtual cathode of the coil, was found to be not simply 3 to 4 cm from the coil center as had been reported. In fact, the study shows that the site of the virtual cathode is affected by the current amplitude and the degree of inhomogeneity of the tissues surrounding the nerve. Furthermore, reversing the coil current direction results in a different level of stimulation but does not affect the virtual cathode position.
520 $a In summary, the research presented in this thesis covers theoretical concepts, experimental aspects, and human studies related to neuro magnetic stimulation. The results of the experiment and the study are consistent with the theoretical analysis. The proposed coil design is novel and offers promise for a better coil system for magnetic nerve stimulation. (Abstract shortened by UMI.)
590 $a School code: 0197.
650 4 $a Engineering, Electronics and Electrical. $3 170927
650 4 $a Engineering, Biomedical. $3 1000005515
650 4 $a Physics, Electricity and Magnetism. $3 1000005526
690 $a 0544
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690 $a 0607
710 2 0 $a McMaster University (Canada). $3 1000005525
773 0 $t Dissertation Abstracts International $g 65-01B.
790 1 0 $a deBruin, Hubert, $e advisor
790 $a 0197
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ86450 $z Download fulltext (下載全文)