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The study of pain with blood oxygen ...

Ibinson, James W.

The study of pain with blood oxygen level dependent functional magnetic resonance imaging.

紀錄類型:	書目-電子資源 : 單行本
正題名/作者:	The study of pain with blood oxygen level dependent functional magnetic resonance imaging./
作者:	Ibinson, James W.
面頁冊數:	142 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-07, Section: B, page: 3420.
Contained By:	Dissertation Abstracts International65-07B.
標題:	Health Sciences, Radiology. -
電子資源:	Download fulltext (下載全文)
ISBN:	049688803X

The study of pain with blood oxygen level dependent functional magnetic resonance imaging.
Ibinson, James W.

The study of pain with blood oxygen level dependent functional magnetic resonance imaging. - 142 p.

Source: Dissertation Abstracts International, Volume: 65-07, Section: B, page: 3420.

Thesis (Ph.D.)--The Ohio State University, 2004.

Using blood oxygen level dependent functional magnetic resonance imaging (BOLD FMRI), the brain areas activated by pain were studied. These initial studies led to interesting new findings about the body's response to pain and to the refinement of one method used in FMRI analysis for correction of physiologic noise (signal fluctuations caused by the cyclic and non-cyclic changes in the cardiovascular and respiratory status of the body).

ISBN: 049688803XSubjects--Topical Terms:

1000005629
Health Sciences, Radiology.

The study of pain with blood oxygen level dependent functional magnetic resonance imaging.
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245 1 4 $a The study of pain with blood oxygen level dependent functional magnetic resonance imaging.
300 $a 142 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-07, Section: B, page: 3420.
500 $a Advisers: Petra Schmalbrock; Robert H. Small.
502 $a Thesis (Ph.D.)--The Ohio State University, 2004.
520 $a Using blood oxygen level dependent functional magnetic resonance imaging (BOLD FMRI), the brain areas activated by pain were studied. These initial studies led to interesting new findings about the body's response to pain and to the refinement of one method used in FMRI analysis for correction of physiologic noise (signal fluctuations caused by the cyclic and non-cyclic changes in the cardiovascular and respiratory status of the body).
520 $a In the first study, evidence was provided suggesting that the multiple painful stimulations used in typical pain FMRI block designs may cause attenuation over time of the BOLD signal within activated areas. The effect this may have on pain investigations using multiple tasks has not been previously investigated.
520 $a The demonstrated BOLD attenuation seems unique to pain studies. Several possible explanations exist, but two of the most likely are neural activity modulation by descending pain inhibitory mechanisms and changing hemodynamics caused by a physiologic response to pain. The second study began the investigation of hemodynamics by monitoring the physiologic response to pain for eight subjects in two phases. Phase one used a combination of standard operating suite monitors and research equipment to characterizing the physiologic response to pain. Phase two collected magnetic resonance quantitative flow images during painful nerve stimulation to test for changes in global cerebral blood flow.
520 $a It is well established that changes in respiration and global blood flow can affect the BOLD response, leading to the final investigation of this dissertation. The brain activation induced by pain for the same eight subjects used in the physiologic response experiments described above was then studied by BOLD FMRI. By including the respiration signal and end-tidal carbon dioxide levels in the analysis of the images, the quantification and removal of image intensity variations correlated to breathing and end-tidal carbon dioxide changes could be performed. The technique generally accepted for this analysis, however, uses respiration signals averaged over a 3 second period. Because normal respiratory rate is approximately one breath every 3 to 5 seconds, it was hypothesized that performing the correction using the average breathing data set would miss much of the actual respiration induced variation in each image. Therefore, a new technique for removing signal that covaries with the actual breathing values present during the collection of each image was introduced. (Abstract shortened by UMI.)
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790 1 0 $a Small, Robert H., $e advisor
790 $a 0168
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