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Airway variability by the forced osc...

Dalhousie University (Canada).

Airway variability by the forced oscillation technique in children with asthma and a novel device for its measurement.

紀錄類型:	書目-電子資源 : 單行本
正題名/作者:	Airway variability by the forced oscillation technique in children with asthma and a novel device for its measurement./
作者:	Lall, Carolyn A.
面頁冊數:	106 p.
附註:	Source: Masters Abstracts International, Volume: 45-03, page: 1557.
Contained By:	Masters Abstracts International45-03.
標題:	Engineering, Biomedical. -
電子資源:	Download PDF (下載PDF全文)
ISBN:	9780494205150

Airway variability by the forced oscillation technique in children with asthma and a novel device for its measurement.
Lall, Carolyn A.

Airway variability by the forced oscillation technique in children with asthma and a novel device for its measurement. - 106 p.

Source: Masters Abstracts International, Volume: 45-03, page: 1557.

Thesis (M.A.Sc.)--Dalhousie University (Canada), 2005.

There is recent evidence that airway diameters change due to airway smooth muscle activity, which is elevated in asthma. Measuring airway variation, by tracking respiratory system resistance (Rrs) over time, may provide a useful indicator of asthma. This could be used in children where asthma most often starts and where there is currently no objective, easy to perform lung function test. This thesis explores variation of Rrs as an indicator of asthma and bronchodilator effect in children and addresses the need for a new lung function measure in children.

ISBN: 9780494205150Subjects--Topical Terms:

1000005515
Engineering, Biomedical.

Airway variability by the forced oscillation technique in children with asthma and a novel device for its measurement.
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502 $a Thesis (M.A.Sc.)--Dalhousie University (Canada), 2005.
520 $a There is recent evidence that airway diameters change due to airway smooth muscle activity, which is elevated in asthma. Measuring airway variation, by tracking respiratory system resistance (Rrs) over time, may provide a useful indicator of asthma. This could be used in children where asthma most often starts and where there is currently no objective, easy to perform lung function test. This thesis explores variation of Rrs as an indicator of asthma and bronchodilator effect in children and addresses the need for a new lung function measure in children.
520 $a In the first part of this thesis, we assessed FEV1 by spirometry and Rrs and standard deviation of Rrs (SDRrs, a measure of variation) by the forced oscillation technique (FOT), before and after a bronchodilator in 40 children with asthma and 30 control children. Rrs was measured during 3 minutes of spontaneous breathing at 7 frequencies between 4 and 34 Hz. Results showed that although baseline FEV1 was no different in control and asthmatic children, baseline Rrs was elevated at all frequencies in asthma and SDRrs was elevated at 4, 6 and 10 Hz in asthma. Administration of a bronchodilator showed small changes in FEV1 and Rrs that were similar in controls and asthmatics. However, SDRrs decreased remarkably more in asthmatics compared with controls. These results likely indicate that asthmatic airways are more variable compared to control airways and this variability in asthmatics can be reduced by a bronchodilator.
520 $a In the second part of this thesis I began the effort of translating this finding to the clinic for the diagnosis and monitoring of patients with asthma. This is particularly important because there are currently few commercially available FOT devices and none that measure variation of Rrs. We designed and assembled a novel FOT prototype device able to measure respiratory impedance and variation of impedance in humans of all ages. The device uses a piston controlled by a linear motor to drive flow oscillations between 4 and 34 Hz. The prototype was demonstrated to be functional and suitable for further performance characterization and commercial development.
520 $a This thesis found airway variability to be a useful and more sensitive indicator of asthma and the effect of a bronchodilator in children and also addressed the need for a new easy to perform clinical FOT tool, completing preliminary development of a new medical device for pulmonary function measurement.
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