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Impact of lipid-lowering agents on t...

Cramer, Caryn L.

Impact of lipid-lowering agents on the incidence of dementia and type 2 diabetes. A population-based cohort study in older Mexican Americans living in the Sacramento area of California.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Impact of lipid-lowering agents on the incidence of dementia and type 2 diabetes. A population-based cohort study in older Mexican Americans living in the Sacramento area of California./
Author:	Cramer, Caryn L.
Description:	83 p.
Notes:	Source: Dissertation Abstracts International, Volume: 68-08, Section: B, page: 5109.
Contained By:	Dissertation Abstracts International68-08B.
Subject:	Gerontology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3276126
ISBN:	9780549174271

Impact of lipid-lowering agents on the incidence of dementia and type 2 diabetes. A population-based cohort study in older Mexican Americans living in the Sacramento area of California.
Cramer, Caryn L.

Impact of lipid-lowering agents on the incidence of dementia and type 2 diabetes. A population-based cohort study in older Mexican Americans living in the Sacramento area of California. - 83 p.

Source: Dissertation Abstracts International, Volume: 68-08, Section: B, page: 5109.

Thesis (Ph.D.)--University of Michigan, 2007.

Lipid-lowering agents (LLAs) such as statins have been shown to have beneficial effects on cardiovascular events in patients with cardiovascular risk factors. The evidence that statins positively affect the incidence of conditions with outcomes sharing a common pathway with cardiovascular disease, such as dementia and type 2 diabetes, is inconsistent in data collected in clinical intervention and observational studies. This dissertation investigates the effects of lipid-lowering agents, the majority of which are statins, on incidence of dementia, on incidence of dementia in diabetics compared to nondiabetics, and on incidence of type 2 diabetes.

ISBN: 9780549174271Subjects--Topical Terms:

168436
Gerontology.

Impact of lipid-lowering agents on the incidence of dementia and type 2 diabetes. A population-based cohort study in older Mexican Americans living in the Sacramento area of California.
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100 1 $a Cramer, Caryn L. $3 1000006686
245 1 0 $a Impact of lipid-lowering agents on the incidence of dementia and type 2 diabetes. A population-based cohort study in older Mexican Americans living in the Sacramento area of California.
300 $a 83 p.
500 $a Source: Dissertation Abstracts International, Volume: 68-08, Section: B, page: 5109.
500 $a Adviser: Mary N. Haan.
502 $a Thesis (Ph.D.)--University of Michigan, 2007.
520 $a Lipid-lowering agents (LLAs) such as statins have been shown to have beneficial effects on cardiovascular events in patients with cardiovascular risk factors. The evidence that statins positively affect the incidence of conditions with outcomes sharing a common pathway with cardiovascular disease, such as dementia and type 2 diabetes, is inconsistent in data collected in clinical intervention and observational studies. This dissertation investigates the effects of lipid-lowering agents, the majority of which are statins, on incidence of dementia, on incidence of dementia in diabetics compared to nondiabetics, and on incidence of type 2 diabetes.
520 $a The study was based on data from a prospective cohort study (Sacramento Area Latino Study of Aging [SALSA]) in a population comprised of 1789 older (>60 years of age) community-dwelling Mexican Americans. A multistage process was used for the evaluation of dementia and cognitive impairment not demented (CIND). Participants who fell below predetermined scoring results were evaluated clinically by an adjudication team. Dementia was diagnosed using DMS-IV criteria. In the analyses, dementia and CIND were combined into one variable: dementia/CIND. Type 2 diabetes status was determined by (1) fasting plasma glucose level ≥126 mg/dL; or (2) use of an antidiabetic medication; or (3) self-report of a doctor's diagnosis of type 2 diabetes. LLA-use was ascertained at each participant's home annually by direct inspection. Cox Proportional Hazards models were used to assess the association between LLA-use and incidence of dementia/CIND and on incidence of type 2 diabetes. LLA-use was modeled as a time-dependent variable.
520 $a Results from this cohort study showed that lipid-lowering agents appeared to decrease the risk of dementia/CIND over a 5-year followup period in a population of Mexican Americans. Nondiabetics who used LLAs or statins had the lowest incidence of dementia/CIND compared to all other combinations of diabetes status and LLA-use. Diabetics who did not use LLAs had the highest incidence of dementia/CIND compared to all other combinations of diabetes status and LLA-use. In the evaluation of the association between LLA-use and incidence of type 2 diabetes, LLAs did not impact the incidence of type 2 diabetes over the 5-year followup period in this population of Mexican Americans.
590 $a School code: 0127.
650 4 $a Gerontology. $3 168436
650 4 $a Health Sciences, Public Health. $3 1000006002
650 4 $a Hispanic American Studies. $3 1000006237
650 4 $a Health Sciences, Epidemiology. $3 1000006403
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690 $a 0573
690 $a 0737
690 $a 0766
710 2 $a University of Michigan. $3 1000005611
773 0 $t Dissertation Abstracts International $g 68-08B.
790 1 0 $a Haan, Mary N., $e advisor
790 $a 0127
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3276126