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The effect of age on bone and its re...

Joiner, Danese M.

The effect of age on bone and its response to mechanical stimulation.

紀錄類型:	書目-電子資源 : 單行本
正題名/作者:	The effect of age on bone and its response to mechanical stimulation./
作者:	Joiner, Danese M.
面頁冊數:	195 p.
附註:	Source: Dissertation Abstracts International, Volume: 71-05, Section: B, page: 3179.
Contained By:	Dissertation Abstracts International71-05B.
標題:	Health Sciences, Aging. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3406309
ISBN:	9781109730432

The effect of age on bone and its response to mechanical stimulation.
Joiner, Danese M.

The effect of age on bone and its response to mechanical stimulation. - 195 p.

Source: Dissertation Abstracts International, Volume: 71-05, Section: B, page: 3179.

Thesis (Ph.D.)--University of Michigan, 2010.

Bone is a specialized tissue system which is able to regulate its own bone mass and architecture to meet the daily demands of its environment. Mechanical loading directly or indirectly influences the activity of cell populations to deposit, maintain, or remove bone tissue as appropriate, which is integral to skeletal adaptation to load With advancing age there are alterations in bone structure and mineralization which are often associated with an increase in osteoporotic fracture risk. The transduction of mechanical cues affects bone structure and mineralization and could be altered with advancing age. Current in vivo and in vitro data suggest age may affect the capacity of bone cells to respond to mechanical stimulation; however the effect of age on this response to mechanical stimulation in the regenerative skeleton is unknown. It was hypothesized that the influence of mechanical factors on the maintenance or repair of bone is influenced by age.

ISBN: 9781109730432Subjects--Topical Terms:

1000006869
Health Sciences, Aging.

The effect of age on bone and its response to mechanical stimulation.
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245 1 4 $a The effect of age on bone and its response to mechanical stimulation.
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500 $a Source: Dissertation Abstracts International, Volume: 71-05, Section: B, page: 3179.
500 $a Adviser: Steven A. Goldstein.
502 $a Thesis (Ph.D.)--University of Michigan, 2010.
520 $a Bone is a specialized tissue system which is able to regulate its own bone mass and architecture to meet the daily demands of its environment. Mechanical loading directly or indirectly influences the activity of cell populations to deposit, maintain, or remove bone tissue as appropriate, which is integral to skeletal adaptation to load With advancing age there are alterations in bone structure and mineralization which are often associated with an increase in osteoporotic fracture risk. The transduction of mechanical cues affects bone structure and mineralization and could be altered with advancing age. Current in vivo and in vitro data suggest age may affect the capacity of bone cells to respond to mechanical stimulation; however the effect of age on this response to mechanical stimulation in the regenerative skeleton is unknown. It was hypothesized that the influence of mechanical factors on the maintenance or repair of bone is influenced by age.
520 $a In this study regenerative specimens were produced in young and old animals. Their response to mechanical loading via nitric oxide (NO), prostaglandin E2 (PGE2), connexin 43 (Cx43), MAP Kinase, and c-fos signaling was assessed via ELISA and western blot and compared to the response of age matched mature bone. Regenerative specimens from young animals had a higher net increase in NO, PGE2, Cx43 and c-fos after mechanical stimulation than regenerative specimens from old animals. The mechanical stimulation of regenerative tissue resulted in a higher net increase of mechanical response molecules than mature bone in both age groups. This was observed at an earlier time point of regeneration in specimens produced in young animals which could initiate earlier remodeling and thus maintain a mean tissue age that is fairly constant and less susceptible to brittle fracture. Progenitor cells from old animals exhibited delayed mineralization and a decrease response to mechanical stimulation throughout differentiation. Primary cells from old donors with appropriate differentiation time and mechanical stimulus may promote bone formation, which is useful for tissue engineering applications. In addition, key differences in mechanical response were highlighted which have the potential for further investigation to develop therapeutics for bone loss in aging populations.
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